Exhibit 10.80

FOURTH AMENDMENT TO STANDARD INDUSTRIAL NET LEASE

(Sorrento Business Complex)

THIS FOURTH AMENDMENT TO STANDARD INDUSTRIAL NET LEASE (“Fourth Amendment”) is made and entered into as of the 5th day of October, 2016, by and between AGP SORRENTO BUSINESS COMPLEX, L.P., a Delaware limited partnership (“Landlord”) and AETHLON MEDICAL, INC., a Nevada corporation (“Tenant”).

R E C I T A L S:

A.             Sorrento Business Complex, a California limited partnership (“Original Landlord”) and Tenant entered into that certain Standard Industrial Net Lease dated as of September 28, 2009 (the (“Original Lease”), as modified by (i) that certain First Amendment to Standard Industrial Net Lease dated as of October 4, 2011 by and between Original Landlord and Tenant (“First Amendment”), (ii) that certain Second Amendment to Standard Industrial Net Lease dated as of October 10, 2014 by and between Landlord and Tenant (the (“Second Amendment”), and (iii) that certain Third Amendment to Standard Industrial Net Lease dated as of October 21, 2015 by and between Landlord and Tenant (the “Third Amendment”), whereby Landlord leases to Tenant and Tenant leases from Landlord certain office space commonly known as Suite 109 in that certain building located and addressed at 11585 Sorrento Valley Road, San Diego, California 92121 (the “Building”). Landlord is the successor-in-interest under the Lease to the Original Landlord. The Original Lease, as modified by the First Amendment, the Second Amendment and the Third Amendment, may be referred to herein as the “Lease.”

B.             By this Fourth Amendment, Landlord and Tenant desire to extend the Lease Term and otherwise modify the Lease as provided herein.

C.             Unless otherwise defined herein, capitalized terms as used herein shall have the same meanings as given thereto in the Lease.

NOW, THEREFORE, in consideration of the foregoing recitals and the mutual covenants contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

A G R E E M E N T:

l.           Remeasurement. Landlord has remeasured the Premises, the Building and the Project (the “Remeasurement”), and according to the Remeasurement, the rentable square footage of the Premises, the Building and the Project shall, effective as of the date of this Fourth Amendment, be (i) 1,703 rentable square feet, (ii) 21,273 rentable square feet and (iii) 127,990 rentable square feet, respectively.

2.            Extension of Lease Term. The Lease Term is hereby extended such that the Lease shall terminate on November 30, 2017 (the “Fourth Amendment Extended Expiration Date”). The period of time from December 1, 2016 through and including the Fourth Amendment Extended Expiration Date shall be referred to herein as the “Fourth Amendment Extended Term.” Tenant shall not have any right to extend the Lease Term beyond the Fourth Amendment Extended Expiration Date.

3.            Minimum Monthly Rent. Notwithstanding anything to the contrary contained in the Lease, during the Fourth Amendment Extended Term, Tenant shall pay Minimum Monthly Rent for the Premises in the amount of Four Thousand Three Hundred Ninety-Three and 74/100 Dollars ($4,393.74).

4.            Tenant's Pro Rata Share. Notwithstanding anything to the contrary contained in the Lease, effective as of the date of this Fourth Amendment, Tenant's Pro Rata Share shall be 8.0054% for the Building and 1.3306% for the Center (i.e., 1,703 rentable square feet in the Premises / 21,273 rentable square feet within the Building and 127,990 rentable square feet within the Center).

5.            Security Deposit. Tenant has previously deposited with Landlord Three Thousand Two Hundred Fifty and 65/100 Dollars ($3,250.65) as a Security Deposit under the Lease. Landlord shall continue to hold such Security Deposit during the Fourth Amendment Extended Term in accordance with the terms and conditions of Article 5 of the Original Lease.

6.            Condition of Premises. Tenant hereby agrees to accept the Premises in its “as-is” condition and Tenant hereby acknowledges that Landlord shall not be obligated to provide or pay for any improvement work or services related to the improvement of the Premises. Tenant also acknowledges that Landlord has made no representation or warranty regarding the condition of the Premises.

7.              Authority. Each individual executing this Fourth Amendment on behalf of Tenant represents and warrants that Tenant is a duly formed and existing entity qualified to do business in California and that Tenant has full right and authority to deliver this Fourth Amendment and that each person signing on behalf of Tenant is authorized to do so.

8.             Brokers. Each party represents and warrants to the other that no broker, agent or finder other than Jones Lang LaSalle ("Broker") negotiated or was instrumental in negotiating or consummating this Fourth Amendment. Each party further agrees to defend, indemnify and hold harmless the other party from and against any claim for commission or finder's fee by any entity other than Broker who claims or alleges that they were retained or engaged by the first party or at the request of such party in connection with this Fourth Amendment. The terms of this Section 8 shall survive the expiration or earlier termination of the term of the Lease, as hereby amended.

9.            Disclosures and Utility Usage Information. Pursuant to Civil Code Section 1938, Landlord states that, as of the date hereof, the Premises has not undergone inspection by a Certified Access Specialist (”CASp”) to determine whether the Premises meet all applicable construction related accessibility standards under California Civil Code Section 55.53. If Tenant is billed directly by a public utility with respect to Tenant's electrical usage at the Premises, upon request, Tenant shall provide monthly electrical utility usage for the Premises to Landlord for the period of time requested by Landlord (in electronic or paper format) or, at Landlord's option, provide any written authorization or other documentation required for Landlord to request information regarding Tenant's electricity usage with respect to the Premises directly from the applicable utility company.

10.          Defaults. Tenant hereby represents and warrants to Landlord that, as of the date of this Fourth Amendment, Tenant is in full compliance with all terms, covenants and conditions of the Lease and that there are no breaches or defaults under the Lease by Landlord or Tenant, and that Tenant knows of no events or circumstances which, given the passage of time, would constitute a default under the Lease by either Landlord or Tenant.

11.          No Further Modification. Except as set forth in this Fourth Amendment, all of the terms and provisions of the Lease shall remain unmodified and in full force and effect.

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IN WITNESS WHEREOF, this Fourth Amendment has been executed as of the day and year first above written.